Principally, `prometheus_client.REGISTRY.register` now requires its argument to
extend `prometheus_client.Collector`.
Additionally, `Gauge.set` is now annotated so that passing `Optional[int]`
causes an error.
The existing implementation of the `python_twisted_reactor_tick_time` metric is pretty useless, because it *only*
measures the time taken to execute timed calls and callbacks from threads. That neglects everything that
happens off the back of I/O, which is obviously quite a lot for us.
To improve this, I've hooked into a different place in the reactor - in particular, where it calls `epoll`. That call is
the only place it should wait for something to happen - the rest of the loop *should* be quick.
I've also removed `python_twisted_reactor_pending_calls`, because I don't believe anyone ever looks at it, and
it's a nuisance to populate.
