diff --git a/Cargo.lock b/Cargo.lock
index f5d9e7b24..4b12b8ef3 100644
--- a/Cargo.lock
+++ b/Cargo.lock
@@ -194,9 +194,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3"
-version = "0.17.2"
+version = "0.17.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "201b6887e5576bf2f945fe65172c1fcbf3fcf285b23e4d71eb171d9736e38d32"
+checksum = "268be0c73583c183f2b14052337465768c07726936a260f480f0857cb95ba543"
 dependencies = [
  "anyhow",
  "cfg-if",
@@ -212,9 +212,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-build-config"
-version = "0.17.2"
+version = "0.17.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "bf0708c9ed01692635cbf056e286008e5a2927ab1a5e48cdd3aeb1ba5a6fef47"
+checksum = "28fcd1e73f06ec85bf3280c48c67e731d8290ad3d730f8be9dc07946923005c8"
 dependencies = [
  "once_cell",
  "target-lexicon",
@@ -222,9 +222,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-ffi"
-version = "0.17.2"
+version = "0.17.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "90352dea4f486932b72ddf776264d293f85b79a1d214de1d023927b41461132d"
+checksum = "0f6cb136e222e49115b3c51c32792886defbfb0adead26a688142b346a0b9ffc"
 dependencies = [
  "libc",
  "pyo3-build-config",
@@ -243,9 +243,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros"
-version = "0.17.2"
+version = "0.17.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "7eb24b804a2d9e88bfcc480a5a6dd76f006c1e3edaf064e8250423336e2cd79d"
+checksum = "94144a1266e236b1c932682136dc35a9dee8d3589728f68130c7c3861ef96b28"
 dependencies = [
  "proc-macro2",
  "pyo3-macros-backend",
@@ -255,9 +255,9 @@ dependencies = [
 
 [[package]]
 name = "pyo3-macros-backend"
-version = "0.17.2"
+version = "0.17.3"
 source = "registry+https://github.com/rust-lang/crates.io-index"
-checksum = "f22bb49f6a7348c253d7ac67a6875f2dc65f36c2ae64a82c381d528972bea6d6"
+checksum = "c8df9be978a2d2f0cdebabb03206ed73b11314701a5bfe71b0d753b81997777f"
 dependencies = [
  "proc-macro2",
  "quote",
diff --git a/changelog.d/14381.misc b/changelog.d/14381.misc
new file mode 100644
index 000000000..1efeb6f37
--- /dev/null
+++ b/changelog.d/14381.misc
@@ -0,0 +1 @@
+Bump pyo3 from 0.17.2 to 0.17.3.
diff --git a/rust/Cargo.toml b/rust/Cargo.toml
index a8e9d7abb..d6e72d4c0 100644
--- a/rust/Cargo.toml
+++ b/rust/Cargo.toml
@@ -23,7 +23,7 @@ name = "synapse.synapse_rust"
 anyhow = "1.0.66"
 lazy_static = "1.4.0"
 log = "0.4.17"
-pyo3 = { version = "0.17.1", features = ["extension-module", "macros", "anyhow", "abi3", "abi3-py37"] }
+pyo3 = { version = "0.17.3", features = ["extension-module", "macros", "anyhow", "abi3", "abi3-py37"] }
 pyo3-log = "0.7.0"
 pythonize = "0.17.0"
 regex = "1.7.0"