diff --git a/changelog.d/14880.bugfix b/changelog.d/14880.bugfix
new file mode 100644
index 000000000..e56c56708
--- /dev/null
+++ b/changelog.d/14880.bugfix
@@ -0,0 +1 @@
+Fix a bug when using the `send_local_online_presence_to` module API.
diff --git a/synapse/handlers/presence.py b/synapse/handlers/presence.py
index 43e4e7b1b..87af31aa2 100644
--- a/synapse/handlers/presence.py
+++ b/synapse/handlers/presence.py
@@ -64,7 +64,13 @@ from synapse.replication.tcp.commands import ClearUserSyncsCommand
 from synapse.replication.tcp.streams import PresenceFederationStream, PresenceStream
 from synapse.storage.databases.main import DataStore
 from synapse.streams import EventSource
-from synapse.types import JsonDict, StreamKeyType, UserID, get_domain_from_id
+from synapse.types import (
+    JsonDict,
+    StrCollection,
+    StreamKeyType,
+    UserID,
+    get_domain_from_id,
+)
 from synapse.util.async_helpers import Linearizer
 from synapse.util.metrics import Measure
 from synapse.util.wheel_timer import WheelTimer
@@ -320,7 +326,7 @@ class BasePresenceHandler(abc.ABC):
         for destination, host_states in hosts_to_states.items():
             self._federation.send_presence_to_destinations(host_states, [destination])
 
-    async def send_full_presence_to_users(self, user_ids: Collection[str]) -> None:
+    async def send_full_presence_to_users(self, user_ids: StrCollection) -> None:
         """
         Adds to the list of users who should receive a full snapshot of presence
         upon their next sync. Note that this only works for local users.
@@ -1601,7 +1607,7 @@ class PresenceEventSource(EventSource[int, UserPresenceState]):
         # Having a default limit doesn't match the EventSource API, but some
         # callers do not provide it. It is unused in this class.
         limit: int = 0,
-        room_ids: Optional[Collection[str]] = None,
+        room_ids: Optional[StrCollection] = None,
         is_guest: bool = False,
         explicit_room_id: Optional[str] = None,
         include_offline: bool = True,
@@ -1688,7 +1694,7 @@ class PresenceEventSource(EventSource[int, UserPresenceState]):
 
             # The set of users that we're interested in and that have had a presence update.
             # We'll actually pull the presence updates for these users at the end.
-            interested_and_updated_users: Collection[str]
+            interested_and_updated_users: StrCollection
 
             if from_key is not None:
                 # First get all users that have had a presence update
@@ -2120,7 +2126,7 @@ class PresenceFederationQueue:
         # stream_id, destinations, user_ids)`. We don't store the full states
         # for efficiency, and remote workers will already have the full states
         # cached.
-        self._queue: List[Tuple[int, int, Collection[str], Set[str]]] = []
+        self._queue: List[Tuple[int, int, StrCollection, Set[str]]] = []
 
         self._next_id = 1
 
@@ -2142,7 +2148,7 @@ class PresenceFederationQueue:
         self._queue = self._queue[index:]
 
     def send_presence_to_destinations(
-        self, states: Collection[UserPresenceState], destinations: Collection[str]
+        self, states: Collection[UserPresenceState], destinations: StrCollection
     ) -> None:
         """Send the presence states to the given destinations.
 
diff --git a/synapse/module_api/__init__.py b/synapse/module_api/__init__.py
index 6153a4825..d22dd19d3 100644
--- a/synapse/module_api/__init__.py
+++ b/synapse/module_api/__init__.py
@@ -1158,7 +1158,7 @@ class ModuleApi:
             # Send to remote destinations.
             destination = UserID.from_string(user).domain
             presence_handler.get_federation_queue().send_presence_to_destinations(
-                presence_events, destination
+                presence_events, [destination]
             )
 
     def looping_background_call(
diff --git a/synapse/notifier.py b/synapse/notifier.py
index 2b0e52f23..a8832a3f8 100644
--- a/synapse/notifier.py
+++ b/synapse/notifier.py
@@ -46,6 +46,7 @@ from synapse.types import (
     JsonDict,
     PersistedEventPosition,
     RoomStreamToken,
+    StrCollection,
     StreamKeyType,
     StreamToken,
     UserID,
@@ -716,7 +717,7 @@ class Notifier:
 
     async def _get_room_ids(
         self, user: UserID, explicit_room_id: Optional[str]
-    ) -> Tuple[Collection[str], bool]:
+    ) -> Tuple[StrCollection, bool]:
         joined_room_ids = await self.store.get_rooms_for_user(user.to_string())
         if explicit_room_id:
             if explicit_room_id in joined_room_ids:
diff --git a/synapse/streams/__init__.py b/synapse/streams/__init__.py
index 2dcd43d0a..c6c8a0315 100644
--- a/synapse/streams/__init__.py
+++ b/synapse/streams/__init__.py
@@ -12,9 +12,9 @@
 # See the License for the specific language governing permissions and
 # limitations under the License.
 
-from typing import Collection, Generic, List, Optional, Tuple, TypeVar
+from typing import Generic, List, Optional, Tuple, TypeVar
 
-from synapse.types import UserID
+from synapse.types import StrCollection, UserID
 
 # The key, this is either a stream token or int.
 K = TypeVar("K")
@@ -28,7 +28,7 @@ class EventSource(Generic[K, R]):
         user: UserID,
         from_key: K,
         limit: int,
-        room_ids: Collection[str],
+        room_ids: StrCollection,
         is_guest: bool,
         explicit_room_id: Optional[str] = None,
     ) -> Tuple[List[R], K]: