diff --git a/changelog.d/11788.feature b/changelog.d/11788.feature
new file mode 100644
index 000000000..dc426fb65
--- /dev/null
+++ b/changelog.d/11788.feature
@@ -0,0 +1 @@
+Remove account data (including client config, push rules and ignored users) upon user deactivation.
\ No newline at end of file
diff --git a/synapse/handlers/sync.py b/synapse/handlers/sync.py
index ffc6b748e..7e2a892b6 100644
--- a/synapse/handlers/sync.py
+++ b/synapse/handlers/sync.py
@@ -1619,7 +1619,7 @@ class SyncHandler:
         # TODO: Can we `SELECT ignored_user_id FROM ignored_users WHERE ignorer_user_id=?;` instead?
         ignored_account_data = (
             await self.store.get_global_account_data_by_type_for_user(
-                AccountDataTypes.IGNORED_USER_LIST, user_id=user_id
+                user_id=user_id, data_type=AccountDataTypes.IGNORED_USER_LIST
             )
         )
 
diff --git a/synapse/rest/client/account_data.py b/synapse/rest/client/account_data.py
index d1badbdf3..58b8adbd3 100644
--- a/synapse/rest/client/account_data.py
+++ b/synapse/rest/client/account_data.py
@@ -66,7 +66,7 @@ class AccountDataServlet(RestServlet):
             raise AuthError(403, "Cannot get account data for other users.")
 
         event = await self.store.get_global_account_data_by_type_for_user(
-            account_data_type, user_id
+            user_id, account_data_type
         )
 
         if event is None:
diff --git a/synapse/storage/databases/main/account_data.py b/synapse/storage/databases/main/account_data.py
index bb3740711..9c19f0965 100644
--- a/synapse/storage/databases/main/account_data.py
+++ b/synapse/storage/databases/main/account_data.py
@@ -158,9 +158,9 @@ class AccountDataWorkerStore(CacheInvalidationWorkerStore):
             "get_account_data_for_user", get_account_data_for_user_txn
         )
 
-    @cached(num_args=2, max_entries=5000)
+    @cached(num_args=2, max_entries=5000, tree=True)
     async def get_global_account_data_by_type_for_user(
-        self, data_type: str, user_id: str
+        self, user_id: str, data_type: str
     ) -> Optional[JsonDict]:
         """
         Returns:
@@ -392,7 +392,7 @@ class AccountDataWorkerStore(CacheInvalidationWorkerStore):
             for row in rows:
                 if not row.room_id:
                     self.get_global_account_data_by_type_for_user.invalidate(
-                        (row.data_type, row.user_id)
+                        (row.user_id, row.data_type)
                     )
                 self.get_account_data_for_user.invalidate((row.user_id,))
                 self.get_account_data_for_room.invalidate((row.user_id, row.room_id))
@@ -476,7 +476,7 @@ class AccountDataWorkerStore(CacheInvalidationWorkerStore):
             self._account_data_stream_cache.entity_has_changed(user_id, next_id)
             self.get_account_data_for_user.invalidate((user_id,))
             self.get_global_account_data_by_type_for_user.invalidate(
-                (account_data_type, user_id)
+                (user_id, account_data_type)
             )
 
         return self._account_data_id_gen.get_current_token()
diff --git a/synapse/visibility.py b/synapse/visibility.py
index 17532059e..1b970ce47 100644
--- a/synapse/visibility.py
+++ b/synapse/visibility.py
@@ -87,7 +87,7 @@ async def filter_events_for_client(
     )
 
     ignore_dict_content = await storage.main.get_global_account_data_by_type_for_user(
-        AccountDataTypes.IGNORED_USER_LIST, user_id
+        user_id, AccountDataTypes.IGNORED_USER_LIST
     )
 
     ignore_list: FrozenSet[str] = frozenset()
diff --git a/tests/replication/slave/storage/test_account_data.py b/tests/replication/slave/storage/test_account_data.py
index 43e324870..1524087c4 100644
--- a/tests/replication/slave/storage/test_account_data.py
+++ b/tests/replication/slave/storage/test_account_data.py
@@ -30,7 +30,7 @@ class SlavedAccountDataStoreTestCase(BaseSlavedStoreTestCase):
         )
         self.replicate()
         self.check(
-            "get_global_account_data_by_type_for_user", [TYPE, USER_ID], {"a": 1}
+            "get_global_account_data_by_type_for_user", [USER_ID, TYPE], {"a": 1}
         )
 
         self.get_success(
@@ -38,5 +38,5 @@ class SlavedAccountDataStoreTestCase(BaseSlavedStoreTestCase):
         )
         self.replicate()
         self.check(
-            "get_global_account_data_by_type_for_user", [TYPE, USER_ID], {"a": 2}
+            "get_global_account_data_by_type_for_user", [USER_ID, TYPE], {"a": 2}
         )