diff --git a/changelog.d/5230.misc b/changelog.d/5230.misc
new file mode 100644
index 000000000..c681bc974
--- /dev/null
+++ b/changelog.d/5230.misc
@@ -0,0 +1 @@
+Remove urllib3 pin as requests 2.22.0 has been released supporting urllib3 1.25.2.
diff --git a/synapse/python_dependencies.py b/synapse/python_dependencies.py
index e3f828c4b..f64baa4d5 100644
--- a/synapse/python_dependencies.py
+++ b/synapse/python_dependencies.py
@@ -74,14 +74,6 @@ REQUIREMENTS = [
     "attrs>=17.4.0",
 
     "netaddr>=0.7.18",
-
-    # requests is a transitive dep of treq, and urlib3 is a transitive dep
-    # of requests, as well as of sentry-sdk.
-    #
-    # As of requests 2.21, requests does not yet support urllib3 1.25.
-    # (If we do not pin it here, pip will give us the latest urllib3
-    # due to the dep via sentry-sdk.)
-    "urllib3<1.25",
 ]
 
 CONDITIONAL_REQUIREMENTS = {