VMs (especially templates) use pre-allocated space. The default private storage max size is 2 GB, but it's very easy to increase as needed. If the disk is completely full, you will get an `Out of disk space` error that may crash your system because Dom0 does not have enough disk space to work. So it's good practice to regularly check disk space usage with the command `df -h` in dom0 terminal.
A system that's out of space should be able to boot, but may be unable to load a desktop manager. In this case it is possible to login to dom0 terminal with Alt + Ctrl + F2. To recover disk space it may be possible to delete files in a userVM by connecting to the userVM terminal:
If this does not work, check the size of /var/lib/qubes/qubes.xml. If it is zero, you'll need to use one of the file backup (stored in /var/lib/qubes/backup), hopefully you have the current data there. Find the most recent one and place in /var/lib/qubes/qubes.xml instead of the empty file.